Formulation and evaluation of buccoadhesive quetiapine fumarate tablets
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چکیده
منابع مشابه
Formulation Development and Evaluation of Orodispersible Tablets of Quetiapine Fumarate by Sublimation Method
The objective of present study was to formulate directly compressible orodispersible tablets of quetiapine fumarate by sublimation method with a view to enhance patient compliance. A full 32 factorial design was used to investigate the effect of two variables viz., concentration of Indion 414 and camphor. Indion 414 (3-5 % w/w) was used as superdisintegrant and camphor (5-15 % w/w) as subliming...
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Buccoadhesive tablets of carvedilol were prepared using HPMC K4M, HPMC K15M and Carbopol 934 as mucoadhesive polymers. Fifteen formulations were developed with varying concentrations of polymers. Formulations of the BC or BD series were composed of HPMC K4M or HPMC K15M in ratios of 1:1 to 1:5 whereas in the BE series Carbopol 934 was used (1:0.25 to 1:1.50). The formulations were tested for in...
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The main objective of the present study was to apply QbD methodology in the development of once-a-day sustained release quetiapine tablets. The quality target product profile (QTPP) was defined after the pharmaceutical properties and kinetic release of the innovator product, Seroquel XR 200 mg. For the D-optimal experimental design, the level and ratio of matrix forming agents and the type of e...
متن کاملFormulation and Evaluation of Buccoadhesive Films of Losartan Potassium
Buccoadhesive buccal delivery systems for losartan potassium in the form of buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like HPMC, Eudragit RS100, Eudragit RL100 and Ethylcellulose with glycerol as plasticizer. The films were characterized on the basis of their physical char...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2012
ISSN: 1984-8250
DOI: 10.1590/s1984-82502012000200017